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. 2024 Jan 31;15:925. doi: 10.1038/s41467-024-45231-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Filovirus RNA copies/g of tissues or copies/ml of blood (rows) sampled from inoculated AFBs (columns) at day post-inoculation (dpi) 5 and 10. Bat identification numbers are noted below. Inoculum RNA load is shown as legend for reference. Blank spaces indicate unavailable samples (tissues, faeces and/or urine). Negative control bats are excluded Stom: Stomach; Sm Int: Small Intestine; Reprod Org: Testes or Uterus; Sk In: Inoculation point in Skin; Ly Nd: Lymph Node (cervical); Sal Gl: Salivary Gland; B M: Bone Marrow; BAT: Brown Adipose Tissue; S: Swab. b Serology (Luminex) of filovirus-inoculated (n = 22), positive (n = 2) and negative (n = 32) control AFBs. Circles show mean values ± SD (horizontal and error bars) of serum samples run in duplicate. Time point 0 shows pre-inoculation results, later re-analysed after euthanasia (5 and 10 dpi). EBOV and MARV positive controls from previously validated positive AFBs serum are shown as grey circles with black outline. Negative controls, including mock-inoculated (C01-C02) and bats kept in BSL4 caging (N01-N08) are shown in coloured circles with light-grey outline. The dashed line denotes the assay cut-off (mean value of negative controls + 3 SD). n = biologically independent animals. Source data are provided as a Source Data file.