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. 2024 Jan 31;15:945. doi: 10.1038/s41467-024-45143-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Schematic representation of the human uterus and identified cell types within the myometrium (left). Visualization of uniform manifold approximation and projection (UMAP) showing an integrative clustering of high-quality cells/nuclei from human myometria (perimenopausal, n = 6; postmenopausal, n = 14) at 0.5 resolution (right). B Dotplot indicating the relative expression of each identified cell type’s top five discriminatory genes (color indicates average expression, while dot size represents the percentage of cells expressing specific genes). Pie charts illustrate the proportion of cells according to menopausal state (perimenopause in blue, postmenopause in yellow) and myometrial zone (light blue -anterior region, dark blue - posterior region, and green - fundus). C Panels displaying the spatial location of endothelial cells, fibroblasts, SMCs, PV cells, and immune cells in the myometrium. D Relative and absolute flows of differentially active signaling pathways during myometrial aging (comparing perimenopausal and postmenopausal myometria). LECs lymphatic endothelial cells, PNS peripheral nervous system, SMCs smooth muscle cells.