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. 2024 Jan 31;15:945. doi: 10.1038/s41467-024-45143-z

Fig. 6. Age-related changes in myometrial cell-to-cell communication.

Fig. 6

Arrows between cell types are colored according to the cell type emitting the signal. The relative thickness of each line depicts the expression-based strength of the interaction between cell types. CCC chord plots for A PDGF, C IGF, E ANGPTL, F EDN, G CXCL and I NRXN signaling pathways in the perimenopausal (left) and postmenopausal myometrium (right). The relative contribution of ligand-receptor pairs to CCC in the B PDGF, D IGF, H CXCL, and J NRXN signaling pathways in the perimenopausal (left) and postmenopausal myometrium (right). PDGF platelet-derived growth factor, IGF insulin growth factor, ANGPTL angiopoietin-like, EDN endothelin, CXCL C-X-C Motif Chemokine Ligand, NRXN nerve transmission-associated neurexin, Fib fibroblasts, Endo endothelial, SMC smooth muscle cells, VSMC vascular smooth muscle cells, PV perivascular, LEC lymphatic endothelium, Mye myeloid, Lym lymphoid, VEN venous, ART arterial, str stressed, stim stimuli-response, con contractile, can canonical, dam damage-response, MAC macrophages, DEND dendritic, NK natural Killer, MONO monocytes, NEUT neutrophils, REG nervous system regulatory fibroblast, MYO myofibroblast, int NRP1 intermediate, Inf immune modulated fibroblast, Cl classic.