Table 2.
Diffusional kurtosis and diffusion tensor metrics from the average thalamus and the white matter measures by groups.
| Metrics | Average white matter atlas | Average thalamus | ||||||
|---|---|---|---|---|---|---|---|---|
| SIVD | AD | NC | ANCOVA | SIVD | AD | NC | ANCOVA | |
| (N = 42) | (N = 50) | (N = 30) | P | (N = 42) | (N = 50) | (N = 30) | P | |
| MK | .88 ± .071 | .99 ± .606 | 1.05 ± .083 | .004b | .81 ± .063 | .89 ± .074 | .92 ± .048 | .031b |
| Kaxial | .44 ± .030 | .45 ± .025 | .46 ± .021 | .112 | .45 ± .044 | .44 ± .043 | .45 ± .023 | .014a |
| Kradial | 1.16 ± .123 | 1.33 ± .098 | 1.41 ± .127 | .019b | .97 ± .087 | 1.0 ± .088 | 1.1 ± .068 | .037b |
| KFA | .35 ± .063 | .38 ± .046 | .39 ± .034 | .866 | .28 ± .087 | .32 ± .069 | .32 ± .038 | .796 |
| MD | 1.20 ± .110 | 1.10 ± .068 | 1.03 ± .069 | .102 | 1.32 ± .256 | 1.18 ± .207 | .98 ± .093 | .010c |
| Daxial | 1.60 ± .093 | 1.52 ± .066 | 1.46 ± .061 | .117 | 1.65 ± .281 | 1.53 ± .233 | 1.29 ± .100 | .003c |
| Dradial | 1.00 ± .123 | .90 ± .072 | .82 ± .075 | .123 | 1.15 ± .245 | 1.01 ± .198 | .823 ± .092 | .019c |
| FA | .31 ± .039 | .35 ± .024 | .37 ± .030 | .182 | .27 ± .035 | .30 ± .035 | .30 ± .024 | .047a |
Data is represented as mean ± SD unless otherwise indicated. Mean/axial/radial diffusivity is presented in units of 10−3mm2s−1. P value from the analysis of covariance (ANCOVA) with covariates including age, education, symptom duration, the volume of white matter hyperintensities, and the number of lacunes are reported. The Tukey post-hoc comparisons are remarked as a: SIVD vs. AD; b: SIVD vs. NC; c: AD vs. NC.
FA = Fractional Anisotropy. KFA = Kurtosis Fractional Anisotropy. MD = Mean Diffusivity. Dradial = Radial Diffusivity. Daxial = Axial Diffusivity. MK = Mean Kurtosis. Kradial = Radial Kurtosis. Kaxial = Axial Kurtosis. SIVD = Subcortical ischemic vascular disease. AD = Alzheimer's disease. NC = normal cognition.
Significant values are in bolditalics.