Table 3.
Discriminant analysis by diffusional kurtosis metrics, diffusion tensor metrics, and macroscopic imaging evaluation.
| Metrics | White matter atlas* | Segregated thalamus analysis§ | ||||||
|---|---|---|---|---|---|---|---|---|
| Overall | CDR ≤ .0.5 | WMH ≤ 15 ml | Lacune ≤ 8 | Overall | CDR ≤ .0.5 | WMH ≤ 15 ml | Lacune ≤ 8 | |
| Scheltens scale† | 72.1 | 72.7 | 67.2 | 72.6 | – | – | – | – |
| Segregated WMH volume* | 63.9 | 75.3 | 85.2 | 72.6 | – | – | – | – |
| MK | 77.9 | 81.8 | 81.0 | 77.4 | 68.9 | 76.6 | 80.3 | 79.0 |
| Kaxial | 68.9 | 76.6 | 73.8 | 72.6 | 56.6 | 64.9 | 59.0 | 56.5 |
| Kradial | 74.6 | 80.5 | 78.7 | 83.9 | 66.4 | 64.9 | 70.5 | 69.4 |
| KFA | 66.4 | 75.3 | 78.7 | 75.8 | 58.2 | 63.6 | 70.5 | 66.1 |
| MD | 76.2 | 80.5 | 80.3 | 77.4 | 63.1 | 68.8 | 75.4 | 71.0 |
| Daxial | 76.2 | 76.6 | 78.7 | 74.2 | 55.7 | 67.5 | 73.8 | 74.2 |
| Dradial | 71.3 | 77.9 | 88.5 | 79.0 | 65.6 | 76.6 | 73.8 | 74.2 |
| FA | 72.1 | 75.3 | 88.5 | 79.0 | 66.4 | 72.7 | 77.0 | 69.4 |
Data are reported by the value of correct classification (%). CDR = Clinical Dementia Rating. WMH = white matter hyperintensities. FA = fractional anisotropy. MD = mean diffusivity. MK = mean kurtosis. KFA = kurtosis fractional anisotropy. Daxial = axial diffusivity. Dradial = radial diffusivity. Kaxial = axial kurtosis. Kradial = radial kurtosis. SIVD = Subcortical ischemic vascular disease. AD = Alzheimer's disease. NC = normal cognition. Macroscopic imaging evaluation included the Scheltens scale and segregated WMH volume.
†A total of 12 subregions averaged from bi-hemispheric ratings are used.
*A total of 16 tracts including the corpus callosum (genu and body parts), and the anterior limb of internal capsule, anterior corona radiata, superior corona radiata, external capsule, cingulum (cingulate gyrus part), and superior longitudinal fasciculus of bi-hemispheres are used.
§A total of 14 sub-regions of the thalamus including the pulvinar, anterior, mediodorsal, ventral–lateral–dorsal, central, ventral-anterior, and ventral–lateral–ventral nuclei are used. Cases number (SIVD/AD/NC): Overall = 42/50/30; CDR ≤ 0.5 = 25/22/30; WMH Volume ≤ 15 ml = 3/32/26; Lacunes ≤ 8 = 8/34/20.