Table 4.
Estimated effect (β coefficients) of diffusional kurtosis and diffusion tensor metrics on global cognition (N = 122).
| Metrics | White matter atlas | Segregated thalamus analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| Regions | β | P | 95% CI | Regions | β | P | 95% CI | |
| MK | CIN_R | .199 | .024 | (6.880,94.025) | C_L | .287 | < .001 | (36.722, 110.999) |
| Kaxial | SCR_L | .222 | .002 | (24.535, 107.512) | VLD_R | .212 | .002 | (21.522, 96.746) |
| Kradial | SCR_R | −.265 | .001 | (−39.707, −9.655) | C_L | .311 | < .001 | (37.771, 100.090) |
| CIN_R | .232 | .004 | (9.148, 47.426) | |||||
| KFA | SCR_R | −.195 | .006 | (−129.004, −21.908) | A_R | −.159 | .023 | (−77.130, −5.943) |
| MD | GCC_R | −.232 | .002 | (−26.495, −6.319) | Medio_R | −.296 | < .001 | (−21.756, −7.146) |
| Daxial | GCC_R | −.241 | .001 | (−29.636, −7.515) | P_L | −.375 | < .001 | (−46.005, −17.181) |
| Dradial | CIN_R | −.190 | .034 | (−46.284, −1.853) | Medio_R | −.287 | < .001 | (−22.153, −6.917) |
| GCC_R | −.161 | .035 | (−20.748, −0.755) | |||||
| FA | SCR_R | −.279 | < .001 | (−181.874, −59.624) | VA_L | −.210 | .004 | (−159.212, −31.029) |
| CIN_R | .252 | .002 | (32.160,142.450) | |||||
Significant regions are reported by stepwise linear regression analysis, with independent variables including targeted imaging metrics showing significant correlation with the total scores of the Cognitive Abilities Screening Instrument. Metrics with a Variance inflation factor (VIF) ≥ 5 are removed. Estimated effect of all metrics is reported after controlling for age, education, symptom duration, the volume of white matter hyperintensities, and the number of lacunes.
CIN = Cingulum. SCR = superior corona radiata. GCC = genu of the corpus callosum. A = anterior nuclei. C = central nuclei. P = pulvinar. VLD = ventral latero-dorsal. Medio = medio-dorsal. VA = ventral-anterior. R/L = Right/Left hemisphere. FA = fractional anisotropy. MD = mean diffusivity. MK = mean kurtosis. KFA = kurtosis fractional anisotropy. Daxial = axial diffusivity. Dradial = radial diffusivity. Kaxial = axial kurtosis. Kradial = radial kurtosis. Mean/axial/radial diffusivity variables are entered in units of 10−3mm2s−1.