Table 5.
Univariate and multivariate analyses of 60-day OS
| Risk factor | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| 60-day OS [%], 95%CI | P-value | HR (95%CI) | P-value | |
| Age (> 60) | 83.1 (77.8–87.3) | 0.006 | 0.726 | |
| (≤ 60) | 93.5 (87.3–96.7) | Reference | ||
| Alb (≤ 3.3 g/dl) | 65.6 (55.0–74.3) | < 0.001 | 4.026 (1.954–8.294) | < 0.001 |
| (> 3.3 g/dl) | 92.6 (87.8–95.5) | Reference | ||
| ASH classification (severe) | 65.0 (40.3–81.5) | 0.003 | 0.996 | |
| (mild and moderate) | 87.8 (83.9–90.9) | Reference | ||
| MHLW classification (severe) | 61.1 (35.3–79.2) | < 0.001 | 0.996 | |
| (mild and moderate I, II) | 87.9 (84.0–90.9) | Reference | ||
| BMI (> 30 kg/m2) | 77.8 (36.5–93.9) | 0.487 | ||
| (≤ 30 kg/m2) | 86.7 (82.7–89.8) | |||
| Current or former smoking | 88.0 (80.8–92.6) | 0.562 | ||
| Never | 85.9 (80.8–89.7) | |||
| Benign disease | 97.6 (84.3–99.7) | 0.028 | 0.095 (0.012–0.750) | 0.026 |
| Malignant | 85.1 (80.8–88.6) | Reference | ||
| MDS | 80.6 (63.5–90.2) | 0.254 | ||
| No MDS | 87.2 (83.1–90.4) | |||
| Leukemia | 89.1 (75.8–95.3) | 0.570 | ||
| No leukemia | 86.2 (81.9–89.6) | |||
| Lymphoma | 83.5 (76.0–88.8) | 0.190 | 0.924 | |
| No lymphoma | 88.4 (83.5–91.9) | Reference | ||
| PCD | 81.4 (68.9–89.2) | 0.196 | 0.331 | |
| No PCD | 87.6 (83.4–90.8) | Reference | ||
| PS (> 2) | 69.1 (58.2–77.6) | < 0.001 | 0.340 | |
| (≤ 2) | 92.1 (88.2–94.7) | Reference | ||
| Relapsed or refractory | 68.3 (55.0–78.5) | < 0.001 | 0.128 | |
| Except for the above | 90.2 (86.3–93.0) | Reference | ||
| Ongoing therapy at diagnosis | 85.2 (79.7–89.4) | 0.379 | ||
| Except for the above | 88.4 (82.2–92.5) | |||
| Oxygen required | 70.6 (62.8–77.1) | < 0.001 | 14.55 (3.378–62.64) | < 0.001 |
| Except for the above | 98.6 (95.6–99.5) | Reference | ||
| Neutrophils (< 1000/µL) | 92.1 (77.5–97.4) | 0.155 | 0.082 | |
| (≥ 1000/µL) | 83.1 (77.9–87.2) | Reference | ||
| Lymphocytes (< 1000/µL) | 82.2 (76.2–86.8) | 0.158 | 0.638 | |
| (≥ 1000/µL) | 89.1 (80.6–94.0) | Reference | ||
| CRP (> 7.0 mg/dl) | 64.5 (51.9–74.6) | < 0.001 | 0.163 | |
| (≤ 7.0 mg/dl) | 89.7 (85.0–93.1) | Reference | ||
OS overall survival, ASH American Society of Hematology, MHLW Ministry of Health Labour and Welfare in Japan, BMI body mass Index, MDS myelodysplastic syndromes, PCD plasma cell dyscrasia, PS performance status, CRP C-reactive protein