Table 1.
Clinical characteristics of antibiotic responsive and antibiotic refractory Lyme arthritis patients
| Antibiotic responsive LA N = 11 |
Antibiotic refractory LA N = 31 |
|
|---|---|---|
| Age, median (range), years | 47 (19–70) | 39.5 (12–78) |
| Sex, no. female: no. male | 2 : 9 | 14 : 17 |
| B. burgdorferi infection | ||
| Bb IgG titer median (range) | 25,600(1,600-102,400) | 25,600 (400-102,400) |
| Bb JF PCR (positive/total tested) | 2/10 | 1/24 |
| Inflammatory markers, median (range) | ||
| ESR | 26 (8–60) | 10 (2–87) |
| CRP | 15.2 (8.1–121.6) | 5.6 (0.4–105.7) |
| HLA-DRB1 risk allelesa | ||
| Patients with at least one high risk DRB1 type/total tested (%) |
4/10 (40%) | 18/28 (64%) |
| Antibiotic treatment duration, median (range) | ||
| All antibiotics prior to sample, days | 36 (0–160) | 123 (1–602)∗∗∗ |
| # resolved with oral antibiotics (%) | 4/11 (36%) | N/A |
| # resolved with IV antibiotics (%) | 7/11 (64%) | N/A |
| IV antibiotics prior to sample, days | 0 | 40 (0–612)∗∗∗ |
| Arthritis characteristics | ||
| Total duration arthritis, median (range), months | 6.5 (3.3–12.2) | 13.7 (5.1–76+)∗∗∗ |
| JF characteristics, median (range) | ||
| WBC count | 10,481 (285-27,922) | 12,150 (3,475-30,750) |
| % neutrophils | 82 (7–92) | 76.5 (0–98) |
| % lymphocytes | 9.5 (0–28) | 14 (0–81) |
LA = Lyme arthritis, Bb = B. burgdorferi, JF = joint fluid, ESR = erythrocyte sedimentation rate, n/a = not applicable, CRP = C-reactive protein, WBC = white blood cell.
∗p < 0.1, ∗∗p < 0.05, ∗∗∗p < 0.01.
a
High risk for antibiotic refractory LA: DRB1∗0101, 0401, 0402, 0404, 0405.