Fig. 1.

Schematic diagram showing the experimental approach for targeted NB therapy (TNT) with PSMA-NB injection (left) followed by TUS irradiation (right) (A). PSMA-targeted NBs selectively internalized into PCa cells. When circulating NBs wash out after 1 h, the remaining NBs in tumors are cavitated using low frequency therapeutic ultrasound (B). Intracellular NB cavitation induces effects which ultimately result in tumor cell apoptosis and reduction of tumor progression. (C).