Table 1.
Expression of various ion channels in HCC.
| Sample type | Channel | Channel full name | Expression level | Ref. |
|---|---|---|---|---|
| Hep3B, HCC tissue | KCa3.1 | Calcium-activated potassium channel subfamily N member 4 | Overexpression | (42) |
| Huh7, Hep3B | KCNQ1 | Voltage-gated potassium channel subfamily Q member 1 | Downregulation | (92) |
| Human HCC tissue | KCNK2 | Two pore domain potassium ion channels | Downregulation | (43) |
| KCNK15 | Two pore domain potassium ion channels | Downregulation | (43) | |
| KCNK17 | Two pore domain potassium ion channels | Downregulation | (43) | |
| KCNK9 | Two pore domain potassium ion channels | Overexpression | (43) | |
| Huh7, Hep3B | KCNJ11 | Inwardly rectifying potassium channel subfamily J member 1 | Overexpression | (44) |
| HepG2, rat hepatocytes, Huh7 HFL | KATP | ATP sensitive potasssium channels | Overexpression | (45) |
| HepG2, Huh7, whole mouse | KCNH1 | Voltage-gated potassium channel subfamily H member 1 | Overexpression | (93) |
| HCC tissue | TRPC6 | Transient receptor potential channel canonical 6 | Overexpression | (46) |
| Huh7 | TRPC1 | Transient receptor potential channel canonical 1 | Overexpression | (47,48) |
| HepG2, and Huh7, DEN models | TRPV1 | Transient receptor potential channel vanilloid 1 | Downregulation | (49,50) |
| HepG2, HepG2 xenografts, and Human HCC tissues | TRPV2 | Transient receptor potential channel vanilloid 2 | Overexpression | (51,52) |
| HCC tissues | TRPV4 | Transient receptor potential channel vanilloid 4 | Overexpression | (53) |
| HepG2 | TRPM7 | Transient receptor potential channel melastatin 7 | Overexpression | (94) |
| 1MEA | TRPV6 | Transient receptor potential channel Vanilloid 6 | Overexpression | (6) |
| SNU449 | T-type Ca2+ | Voltage-gated calcium channels | Overexpression | (95) |
| Huh7, Hep3B, SNU-387, PLC/PRF/5 | P2×3 | Purinergic receptor P2X ligand-gated ion channel 3 | Overexpression | (96) |
| HCC tissues, MHCC97H | CLIC1 | Chloride intracellular channel 1 | Overexpression | (97–100) |
| HepG2 | VGSCβ1 | Voltage-gated sodium channel beta subunit 1 | Down-regulation | (101) |
| Rat HCC tissue | Nav1.2 | Voltage-gated sodium channel alpha subunit 2 | Overexpression | (102) |
| Hep3B, Huh7 | AQP5 | Aquaporin 5 | Overexpression | (103) |
| Huh-7, HLE, HepG2, SMMC-7721, HCC tissue | AQP9 | Aquaporin 9 | Down-regulation | (104) |