Table 2.
Evaluation of different combinations of variables to predict the rituximab class concentrations
| Association of Variables | Accuracy |
|---|---|
| Age + Gender + BSA | 0.4559 |
| Age + Gender + BSA + GFR on D0 | 0.5294 |
| Age + Gender + BSA + GFR on D0 + CD19 on D0 | 0.5 |
| Age + Gender + BSA + GFR on D0 + anti-PLA2R1 antibody titer on D0 | 0.5441 |
| Age + Gender + BSA + GFR on D0 + anti-PLA2R1 antibody titer on D0 + weight | 0.5417 |
| Age + Gender + BSA + GFR on D0 + anti-PLA2R1 antibody titer on D0 + height | 0.5441 |
| Age + Gender + BSA + GFR on D0 + anti-PLA2R1 antibody titer on D0 + BMI | 0.4559 |
| Age + Gender + BSA + GFR on D0 + anti-PLA2R1 antibody titer on D0 + serum albumin on M0 | 0.6324 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 | 0.6471 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 | 0.6618 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 + use of angiotensin-converting enzyme inhibitors | 0.6471 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 + use of angiotensin II receptor blockers | 0.6471 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 + use of furosemide | 0.6471 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 + use of hydrochlorothiazide | 0.6471 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 + serum albumin on D15 | 0.72 |
| Age + Gender + BSA + serum albumin on D0 + serum creatinine on D0 + serum albumin on D15 + serum creatinine on D15 | 0.72 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on M0 + serum creatinine on D0 + serum albumin on D15 + serum creatinine on D15 | 0.794 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 + serum albumin on D15 + serum creatinine on D15 + number of visits | 0.748 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 + serum albumin on D15 + serum creatinine on D15 + proteinuria on D0 | 0.7647 |
| Age + Gender + BSA + anti-PLA2R1 antibody titer on D0 + serum albumin on D0 + serum creatinine on D0 + serum albumin on D15 + serum creatinine on D15 + proteinuria on D15 | 0.75 |
| All predictors (N = 21) | 0.7353 |
BSA, body surface area; D0, day-0; D15, day-15; GFR, glomerular filtration rate; PLA2R1, phospholipase A2 receptor type 1.