Table 3.
GI toxicity characteristics at time of infliximab failure
| Variable | (N=78) |
| Response to infliximab | |
| Nil | 18 (23%) |
| Partial (improvement, but not to ≤G1) | 20 (26%) |
| Initial (initial improvement to ≤G1, then relapse) | 40 (51%) |
| Number of infliximab doses | |
| Median (range) | 2 (1, 6) |
| Endoscopy post infliximab | |
| No | 17 (22%) |
| Yes | 61 (78%) |
| Degree of inflammation endoscopically post infliximab | |
| Endoscopically normal | 11 (18%) |
| Rectum only | 4 (7%) |
| Sigmoid only | 4 (7%) |
| Left-sided (sigmoid+rectum) | 11 (18%) |
| Pancolitis | 27 (45%) |
| Upper gastrointestinal tract only | 3 (4%) |