Table 1.
Ten deprescribing articles for newcomers to the field.
| First author, year | Title | Comments |
|---|---|---|
| Critical concepts | ||
| Holmes 200610 | Reconsidering medication appropriateness for patients in late life | Introduction to key aspects that inform deprescribing such as time to benefit, life expectancy, goals of care, balance of benefits and harms of medications |
| Boyd 200411 | Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance | An examination of the implications of treatment guidelines for single diseases on older adults with multiple health problems |
| High level overviews | ||
| Scott 201512 | Reducing inappropriate polypharmacy: the process of deprescribing | A framework for the process of deprescribing, highlighting key steps and considerations |
| Reeve 201713 | Deprescribing: a narrative review of the evidence and practical recommendations for recognizing opportunities and taking action | Narrative review covering ‘what is deprescribing’, the potential benefits and harms, and barriers, enablers and opportunities for taking action (with references for further reading) |
| Major trials | ||
| Tannenbaum 201414 | Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education: the EMPOWER cluster randomized trial | Trial of educating patients using a deprescribing patient empowerment intervention delivered through community pharmacies |
| Sheppard 202015 | Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older: The OPTIMISE Randomized Clinical Trial | Contemporary trial incorporating a novel approach in the field (noninferiority) to examine the effects of deprescribing |
| The complexity of deprescribing | ||
| Doherty 202016 | Barriers and facilitators to deprescribing in primary care: a systematic review | A comprehensive review highlighting the challenges of deprescribing in routine care |
| Weir 202217 | Consumer attitudes towards deprescribing: a systematic review and meta-analysis | A summary of papers which have examined how consumers across the world feel about deprescribing |
| Knowledge synthesis in deprescribing | ||
| Gnjidic 202218 | Achieving sustainable healthcare through deprescribing | Introduction to and synthesis of a collection of Cochrane Reviews related to deprescribing that discusses the challenges of evidence synthesis in this field |
| Farrell 201619 | Methodology for developing deprescribing guidelines: using evidence and GRADE to guide recommendations for deprescribing | A framework for synthesizing deprescribing evidence into clinical practice guidelines for clinicians and patients, see deprescribing.org for related work |