Table 2. Prevalence of Familial Hypercholesterolemia (FH) Variants by Levels of Detreated Low-Density Lipoprotein Cholesterol (LDL-C), Sex, Race, and Ethnicity.
| FH variant status | FH variant | No FH variant | Difference in detreated LDL-C, mean (SE) | ||
|---|---|---|---|---|---|
| No. (%) | Detreated LDL-C, mean (SD) | No. (%) | Detreated LDL-C, mean (SD) | ||
| Detreated LDL-C | |||||
| <130 mg/dL | 8 (0.1) | 114.5 (13.4) | 11 786 (99.9) | 101.8 (19.8) | 12.7 (4.8) |
| 130-189 mg/dL | 22 (0.3) | 165.8 (15.7) | 8273 (99.7) | 152.4 (15.8) | 13.4 (3.3) |
| ≥190 mg/dL | 33 (2.5) | 257.6 (66.7) | 1304 (97.5) | 218.5 (31.4) | 39.1 (11.6) |
| Sex | |||||
| Male | 26 (0.3) | 206.7 (80.3) | 9359 (99.7) | 128.9 (37.1) | 72.3 (12.2) |
| Female | 37 (0.3) | 207.8 (70.3) | 12 004 (99.7) | 128.1 (39.6) | 65.9 (9.1) |
| Race and ethnicitya | |||||
| Hispanic | 1 (0.1) | 252.0 | 1022 (99.9) | 126.9 (36.0) | 125.1 |
| Non-Hispanic Black | 20 (0.3) | 183.4 (58.9) | 6019 (99.7) | 126.8 (40.4) | 56.6 (13.2) |
| Non-Hispanic White | 36 (0.3) | 229.1 (79.2) | 13 716 (99.7) | 129.7 (38.1) | 99.4 (13.2) |
| Otherb | 6 (1.0) | 149.3 (23.4) | 606 (99.0) | 120.1 (30.3) | 29.2 (9.6) |
a
Race and ethnicity data were self-reported by the participants using fixed categories and reported because of reported associations with LDL-C levels and CHD outcomes.
b
Other includes Asian or Pacific Islander, Native American, and other/multiple races, consolidated owing to small numbers.