Table 3. Hazard Ratios for Coronary Heart Disease Associated With Familial Hypercholesterolemia (FH) Variant Status.

FH variant status	Mean (SD)		Incidence rate per 1000 person-years (95% UI)	Hazard ratio (95% CI)
	Baseline LDL-C	Time-weighted LDL-Ca		Model 1b	Model 2c	Model 3d
Among participants with baseline detreated LDL-C 130-189 mg/dL (n = 8295)
No FH variant	152.4 (15.8)	133.0 (11.7)	8.7 (8.3-9.2)	1 [Reference]	1 [Reference]	1 [Reference]
FH variant	165.8 (15.7)	181.2 (15.9)	11.5 (4.8-27.7)	2.9 (1.4-6.0)	2.6 (1.2-5.4)	1.3 (0.6-2.9)
Among participants with baseline detreated LDL-C ≥190 mg/dL (n = 1337)
No FH variant	218.5 (31.4)	164.9 (18.2)	12.2 (10.9-13.6)	1 [Reference]	1 [Reference]	1 [Reference]
FH variant	257.6 (66.7)	243.9 (36.7)	14.0 (7.5-26.0)	2.6 (1.4-4.9)	2.4 (1.3-4.4)	1.9 (0.9-3.9)

Abbreviations: LDL-C, low-density lipoprotein cholesterol; UI, uncertainty interval.

^a Time-weighted mean (SD) LDL-C from age 20 years to study baseline was estimated using linear mixed-effects model.

^b Model 1 is adjusted for race, ethnicity, sex, smoking status, body mass index, high-density lipoprotein cholesterol, systolic blood pressure, diabetes, use of lipid-lowering medications, and use of antihypertensive medications and stratified by study cohort.

^c Model 2: model 1 and LDL-C at study baseline.

^d Model 3: model 1 and time-weighted average LDL-C from age 20 years to study baseline.