Table II.
Demographic data. Comparison of patient profiles in the parent study SYNAPSES (Europe) and the post-hoc analysis of the Spanish study population (Spain).
| Total number of evaluable patients | Patients aged >75 years | Patients with relevant comorbidities | Patients with psychiatric conditions | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
||||||
| Spain n = 511 (100%) | Europe n = 1558 (100%) | Spain n = 131 (25.6%) | Europe n = 391 (25.1%) | Spain n = 373 (73.0%) | Europe n = 1103 (70.8%) | Spain n = 249 (48.7%) | Europe n = 661 (42.4%) | ||
| Sex (n, %) | Male | 289 (56.6%) | 961 (61.7%) | 59 (45.0%) | 221 (56.5%) | 200 (53.6%) | 665 (60.3%) | 119 (47.8%) | 356 (53.9%) |
|
|
|
|
|
||||||
| Female | 222 (43.4%) | 597 (38.3%) | 72 (55.0%) | 170 (43.5%) | 173 (46.4%) | 438 (39.7%) | 130 (52.2%) | 305 (46.1%) | |
|
|
|
|
|
||||||
| Age at enrollment (years: mean ± SD) | 68 ± 10.3 | 68.4 ± 9.7 | 79.9 ± 3.0 | 79.7 ± 3.1 | 70 ± 9.1 | 70.0 ± 8.7 | 68.7 ± 9.9 | 68.3 ± 9.4 | |
|
|
|
|
|
||||||
| Race (n, %) | Caucasian | 507 (99.2%) | 1543 (99.0%) | 131 (100%) | 389 (99.5%) | 369 (98.9%) | 1094 (99.2%) | 247 (99.2%) | 658 (99.5%) |
|
|
|
|
|
||||||
| Other | 4 (0.8%) | 15 (1.0%) | 0 (0.0%) | 2 (0.5%) | 4 (1.1%) | 9 (0.8%) | 2 (0.8%) | 3 (0.5%) | |
|
|
|
|
|
||||||
| Diagnosis (n, %) | Idiopathic PD | 500 (97.8%) | 1542 (99.0%) | 129 (98.5%) | 389 (99.5%) | 367 (98.4%) | 1094 (99.2%) | 243 (97.6%) | 653 (98.8%) |
|
|
|
|
|
||||||
| Atypical Parkinsonism | 9 (1.8%) | 12 (0.8%) | 2 (1.5%) | 2 (0.5%) | 5 (1.3%) | 7 (0.6%) | 5 (2.0%) | 6 (0.9%) | |
|
|
|
|
|
||||||
| Juvenile PD | 2 (0.4%) | 4 (0.3%) | 0 (0.0%) | 0 (0.0%) | 1 (0.3%) | 2 (0.2%) | 1 (0.4%) | 2 (0.3%) | |
|
|
|
|
|
||||||
| Time from diagnosis (years: mean ± SD) | 8.1 ± 5.6 | 7.9 ± 5.3 | 8.1 ± 5.2 | 7.9 ± 5.3 | 8.0 ± 5.5 | 7.8 ± 5.3 | 8.9 ± 6.1 | 8.4 ± 5.5 | |
|
|
|
|
|
||||||
| Time from onset of symptoms (years: mean ± SD) | 8.9 ± 5.5 | 8.8 ± 5.5 | 8.8 ± 4.9 | 8.9 ± 5.5 | 8.8 ± 5.3 | 8.7 ± 5.4 | 9.5 ± 6.1 | 9.3 ± 5.5 | |
|
|
|
|
|
||||||
| Age at onset of symptoms (years: mean ± SD) | 58.6 ± 11.5 | 59.3 ± 11.0 | 71.2 ± 5.5 | 70.9 ± 6.5 | 60.9 ± 10.2 | 61.0 ± 10.1 | 58.8 ± 11.5 | 58.8 ± 10.7 | |
|
|
|
|
|
||||||
| Hoehn & Yahr stage (n, %) | 1 | 20 (4.2%) | 82 (5.3%) | 1 (0.8%) | 5 (1.3%) | 16 (4.5%) | 45 (4.1%) | 6 (2.5%) | 21 (3.1%) |
|
|
|
|
|
||||||
| 2 | 295 (62.0%) | 793 (50.9%) | 58 (48.7%) | 143 (36.6%) | 206 (58.4%) | 550 49.9%) | 129 (54.4%) | 307 (46.4%) | |
|
|
|
|
|
||||||
| 3 | 139 (29.2%) | 421 (27.1%) | 52 (43.7%) | 144 (36.9%) | 114 (32.3%) | 325 (29.5%) | 85 (35.9%) | 215 (32.5%) | |
|
|
|
|
|
||||||
| 4 | 21 (4.4%) | 88 (5.6%) | 8 (6.7%) | 40 (10.2%) | 16 (4.5%) | 70 (6.3%) | 17 (7.2%) | 63 (9.5%) | |
|
|
|
|
|
||||||
| 5 | 1 (0.2%) | 6 (0.4%) | 0 (0.0%) | 4 (1.0%) | 1 (0.3%) | 5 (0.5%) | 0 (0.0%) | 4 (0.6%) | |
Percentages (%) are calculated by column. n: number of patients; PD: Parkinson’s disease; SD: standard deviation.