Table 4.
Summary of drug interaction for the combination of RAB and azoles.
| Median MIC a (range) of durg (μg/mL) | FICI b results (n) | ||||||
|---|---|---|---|---|---|---|---|
| Alone | In combination | S | I | A | |||
| Azoles | RAB | Azoles | RAB | ||||
| A. fumigatus (n=14) | |||||||
| ITC | 2 (1->32) | >128 | 0.75 (0.25->32) | 64 (2->128) | 6 | 8 | 0 |
| POS | 1 (0.5-2) | >128 | 0.25 (0.06-2) | 32 (2-64) | 12 | 2 | 0 |
| VRC | 0.75 (0.25-32) | >128 | 0.75 (0.25-32) | 2 | 0 | 14 | 0 |
| Non-fumigatus Aspergillus (n=13) | |||||||
| ITC | 1 (0.5-4) | >128 | 1 (0.25-2) | 2 (2-128)) | 4 | 9 | 0 |
| POS | 1 (0.5-1) | >128 | 0.13 (0.06-1) | 32 (2-64) | 12 | 1 | 0 |
| VRC | 0.5 (0.25-2) | >128 | 0.5 (0.25-2) | 2 (2-32) | 1 | 12 | 0 |
| Dematiaceous fungi (n=24) | |||||||
| ITC | 1 (0.13-2) | >128 | 0.5 (0.13-1) | 2 (2->128) | 2 | 22 | 0 |
| POS | 0.5 (0.25-1) | >128 | 0.13 (0.03-0.5) | 32 (4->128) | 19 | 5 | 0 |
| VRC | 0.19 (0.06-2) | >128 | 0.25 (0.06-1) | 2 (2-32) | 2 | 20 | 2 |
| Candida spp. (n=16) | |||||||
| ITC | 1 (0.13-2) | >128 | 0.5 (0.13-2) | 2 (2-64) | 5 | 10 | 1 |
| POS | 0.5 (0.13-2) | >128 | 0.5 (0.13-2) | 2 (2-32) | 0 | 16 | 0 |
| VRC | 0.25 (0.13-4) | >128 | 0.25 (0.13-4) | 2 | 0 | 16 | 0 |
| FLC | 4 (0.25-32) | >128 | 3 (0.25-16) | 3 (1-4) | 2 | 14 | 0 |
a
The MIC is the concentration achieving 100% growth inhibition for Aspergillus spp. and dematiaceous fungi and 50% growth inhibition for Candida spp., respectively.
b
FICI, fractional inhibitory concentration index; S, synergy (FICI of ≤ 0.5); I, no interaction (indifference) (0.5<FICI ≤ 4); A, antagonism (FICI of >4).