Table 1.

SNIP1 linked to Cancers.

Diseases	Methods	Markers	Conclusion	Reference
Non-small cell lung cancers (NSCLCs)	The expression of miR-138-5p and SNIP1 were analyzed in lung cancer serum samples. The effects of miR-138-5p on cell proliferation and metastasis were investigated by CCK-8, colony formation tests, Western blot were used to detect the protein expression of SNIP1 and related genes.	Cyclin D1 E-cadherin GAPDH SNIP1 miR-138-5p c-Myc	SNIP1 competes with HDAC bind to RB and decrease HDAC activity in vitro. Down-regulation of SNIP1 decreased the colony-forming ability of lung cancer cells. What is more, miR-138-5p suppressed lung cancer cell proliferation and migration by targeting SNIP1.	[28]
Triple-negative breast cancer (TNBC)	Mass spectrometry (MS) analysis to identify KMT5A. Coimmunoprecipitation assay and LC-MS/MS analysis SNIP1-interacting proteins from MDA-MB-231 cells. Western blot and qPCR were used to detect the protein expression of SNIP1	MARK4 c-MYC KAT2A SNIP K301 KMT5A	Methylation of SNIP1 by KMT5A enhances key oncogenic pathway-Hippo signaling, thereby promoting TNBC metastasis. KMT5A-mediated SNIP1 methylation could be regarded as an essential step for c-MYC/KAT2A complex formation and c-MYC target activation.	[29]

(Supplemental). SNIP1 linked to Cancers
Diseases	Methods	Markers	Conclusion	Reference
Pancreatic ductal adenocarcinoma (PDAC)	Surgically removed PDAC samples. The c-Myc RIP-seq analysis was performed on PDAC cells，and a panel of c-Myc-associated lncRNAs was identified.	BCAN-AS1 c-Myc SNIP1 SKP2 PAICS MCM7 HADHB MYO18A KIF5B	SNIP1 binds to BCAN-AS1 by recognizing its m6A modification. This progress block ubiquitination and degradation of c-Myc mediated by S-phase kinase-associated protein 2 (SKP2), then effectively inhibit tumor growth and metastasis.	[31]
Cervical cancer	The expression of miR-29a-3p and SNIP1 were analyzed in cervical cancer HeLa cells. The protein expression of SNIP1 and related genes were measured through Western blot and RT-qPCR.	SNIP1 HSP27 c-Myc cyclin D1 MMP9 MAPK1 N-cadherin E-cadherin CDK2	miR-29a-3p suppressed the migration and proliferation in HeLa cells by directly targeting SNIP1.And miR-29a-3p/SNIP1 axis could provide new insight into the development of cervical cancer.	[32]
Osteosarcoma	Use the qRT-PCR assessed circUSP48, miR-335 and SNIP1 expression in OS cell lines and tissues. Sanger sequencing, RNase R processing and FISH detection were performed for circUSP48 validation.	SNIP1 MMP-2 MMP-7 c-Myc NF-κB p65 UBE2G1 KRTAP10-1 CRTAC1 PEBP4	SNIP1 is a direct target of miR-335, and miR-335 inhibit SNIP1exprssion. Inaddition, overexpression of SNIP1 weakens the inhibitory effect of miR-335. SNIP1 may be a potential target for future osteosarcoma treatment.	[34]
Colorectal cancer (CRC)	Tumour tissues and matched normal fresh tissues were collected from three CRC patients. Immunohistochemistry, western blotting, and quantitative real-time PCR analysis were performed to test the level of related index.	MKRN1 SNIP1 TRA2A LUC7L HT29 HCT116 HCT15 RKO	SNIP1 exhibits potential as a significant biomarker in preventing and treating colorectal cancer. Additionally, the MKRN1/SNIP1/TGF-β pathway might be regarded as a novel target for the development of anti-metastatic therapeutics in CRC.	[35]