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. Author manuscript; available in PMC: 2024 Aug 16.
Published in final edited form as: Bioconjug Chem. 2023 Aug 4;34(8):1380–1386. doi: 10.1021/acs.bioconjchem.3c00254

Figure 1a.

Figure 1a.

Comparison of commercial availability of carboxylic acid bearing bifunctional alcohols and aldehydes. b. Current literature methods for DNA-compatible oxidation of alcohols in DNA-encoded libraries (DELs). c. New DNA-compatible method for oxidation of primary activated alcohols to aldehydes as a precursor to DNA-compatible aldehyde transformations (Benzimidazole formation, Reductive amination, Horner-Wadsworth-Emmons Olefination).