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. Author manuscript; available in PMC: 2024 Aug 16.

Published in final edited form as: Bioconjug Chem. 2023 Aug 4;34(8):1380–1386. doi: 10.1021/acs.bioconjchem.3c00254

Figure 3. — Oxidation of diverse, DNA-linked, primary activated alcohols to the corresponding aldehydes. Reaction conditions: DNA (1 equiv, 1 nmol), Cu(ClO₄)₂ (100 equiv, 20 μL of 5 mM stock in MeCN), TEMPO (100 equiv, 20 μL of 5 mM stock in MeCN), bipyridine (100 equiv, 20 μL of 5 mM in MeCN), H₂O/250 mM borate buffer pH 9.5/MeCN (v/v/v 52.5/16.5/31 −194 μL total volume), rt, 12 hours.

Figure 3. — Oxidation of diverse, DNA-linked, primary activated alcohols to the corresponding aldehydes. Reaction conditions: DNA (1 equiv, 1 nmol), Cu(ClO₄)₂ (100 equiv, 20 μL of 5 mM stock in MeCN), TEMPO (100 equiv, 20 μL of 5 mM stock in MeCN), bipyridine (100 equiv, 20 μL of 5 mM in MeCN), H₂O/250 mM borate buffer pH 9.5/MeCN (v/v/v 52.5/16.5/31 −194 μL total volume), rt, 12 hours.