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. 2024 Jan 19;18(4):2928–2947. doi: 10.1021/acsnano.3c07678

Figure 6.

Figure 6

Reverse transcription accelerates capsid integrity loss but does not affect the lag time between integrity loss and uncoating. (A) Waiting times for all CA*:Gag-iYFP integrity loss and uncoating events with DMSO, 10 μM NVP, and 10 μM RAL treatment. Median and interquartile range are plotted. Average integrity loss and uncoating times are displayed above each column with standard deviations. Temporal resolution is ∼11 min per frame. (B) Uncoating efficiency of DMSO and NVP treated cells, with 19.1% reduction in NVP treated CA*iYFP cores, with minimal effect with RAL present. (C) Cumulative distributions of the integrity loss and terminal uncoating lag times in DMSO, NVP, and RAL treated cells. Statistical analysis of data performed with Mann–Whitney rank sum test.