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. 2024 Jan 18;18(4):3382–3396. doi: 10.1021/acsnano.3c10339

Figure 6.

Figure 6

Immune activation by PEG-cross-linked AP205 VLPs. C57BL/6J SPF mice were subcutaneously injected with native (n = 7), PEG-cross-linked (n = 13), or PEGylated but not cross-linked (n = 3) AP205 VLPs on Day 0 and Day 10 and sacrificed on Day 20. Serum antibody (IgG) titers against (a) AP205 coat protein and (b) PEG was measured by ELISA. Statistical significance was determined by ordinary one-way ANOVA with Dunnett’s multiple comparisons test, with a single pooled variance on log-normalized data (*P = 0.0332; **P = 0.0021; ***P = 0.0002). Red arrow in (a) indicates detection limit.