Table 3.
Analysis of prognostic factors associated with OS
| Prognostic factor | Bivariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (CI 95%) | p* | β (SE) | HR (CI 95%) | p* | |
| Karnofsky | |||||
| ≥ 90 | 1 | - | 1 | ||
| < 90 | 2.452 (2.085 – 2.883) | < 0.0001 | 0.616 (0.085) | 1.851 (1.566 – 2.188) | < 0.0001 |
| Age (years) | |||||
| ≥ 60 | 1 | - | 1 | ||
| < 60 | 0.907 (0.781 – 1.053) | 0.201 | -0.225 (0.082) | 0.798 (0.679 – 0.938) | 0.006 |
| Marital status | |||||
| Single, widowed or divorced | 1 | - | 1 | ||
| Married or common-law union | 1.133 (0.998 – 1.286) | 0.053 | -0.043 (0.066) | 0.958 (0.841 – 1.092) | 0.522 |
| Education level | |||||
| No studies | 1 | - | 1 | ||
| Elementary school or higher | 0.865 (0.761 – 0.983) | 0.027 | -0.085 (0.071) | 0.918 (0.799 – 1.056) | 0.231 |
| Area of residence | |||||
| Urban | 1 | - | 1 | ||
| Rural o suburban | 0.848 (0.745 – 0.965) | 0.013 | -0.316 (0.071) | 0.729 (0.635 – 0.838) | < 0.0001 |
| SES | |||||
| 3–6 | 1 | - | 1 | ||
| 1–2 | 1.049 (0.752 – 1.463) | 0.78 | 0.272 (0.08) | 1.315 (1.123 – 1.539) | 0.001 |
| Clinical stage of CC | |||||
| ES | 1 | - | 1 | ||
| LAS | 5.316 (3.819 – 7.401) | < 0.0001 | 1.635 (0.169) | 5.131 (3.683 – 7.149) | < 0.0001 |
| AS, recurrent and persistent | 19.666 (13.87 – 27.884) | < 0.0001 | 2.707 (0.181) | 14.982 (10.512 – 21.353) | < 0.0001 |
| Cancer treatment | |||||
| Treatment | 1 | - | 1 | ||
| No treatment | 9.975 (8.141 – 12.222) | < 0.0001 | 1.9 (0.109) | 6.686 (5.405 – 8.272) | < 0.0001 |
CI confidence interval, SE standard error, SES socioeconomic status, CC cervical cancer, ES early stages, LAS locally advanced stages, AS advanced stages
*Risk model by Cox regression. HR Hazard Ratio