Table 3.
Adjusted probabilities of cholestatic liver injury after severe burn injury.
| Risk factors | Adjusted odds ratio (95% CI) | p value |
|---|---|---|
| Ketamine-restricted period | 0.16 (0.04–0.50) | 0.003 |
| Inhalation injury | 4.33 (1.51–13.67) | 0.008 |
| Number of surgical procedures | 1.18 (1.04–1.37) | 0.018 |
| Parenteral nutrition | 4.29 (1.10–18.10) | 0.039 |
| Acute respiratory distress syndrome | 2.41 (0.81–7.29) | 0.113 |
| Renal replacement therapy | 5.53 (1.86–17.03) | 0.002 |
| Sepsis | 5.53 (1.49–26.91) | 0.017 |
| Observations | 276 | |
| R2 Tjur | 0.506 |
Risks were computed using backward stepwise binary logistic regression models adjusted for body surface area burned, full thickness body surface burned, severity of illness, intensity of critical care, and total sufentanil and midazolam dose. Cholestatic liver injury was serum ALP ≥1.5 × N with GGT ≥3 × N and TBIL >ULN. ALP, alkaline phosphatase; TBIL, total bilirubin; GGT, gamma glutamyl transferase; N, normal; ULN, upper limit of normal.