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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: J Inherit Metab Dis. 2022 Dec 11;46(2):335–347. doi: 10.1002/jimd.12577

Figure 7. Retinal changes in Sumf1S153P/S153P and Sumf1A277V/A277V mice.

Figure 7.

(A-B) Electroretinography (ERG) on 6-month-old Sumf1S153P/S153P (S153P/S153P; n=8), Sumf1A277V/A277V (A277V/A277V, n=10) and control wild type Sumf1+/+ (+/+, n=10) mice. A- and B-wave responses are plotted as a function of stimulus intensity. Mean ± SEM is shown. Two-way ANOVA, Sidak’s multiple comparison test; *** p-value < 0.005, ** p-value < 0.01, *p-value < 0.05. (C) Outer nuclear layer (ONL) thickness in 24-month-old Sumf1S153P/S153P (S153P/S153P), Sumf1A277V/A277V (A277V/A277V) and control Sumf1+/+ (+/+) mice. Magnification 20x scale bar 50 μm. (D) ONL thickness was measured in central retina sections at 10 equidistant positions from the nasal and temporal retina, respectively in Sumf1+/+mice (n=4), Sumf1S153P/S153P (S153P/S153P; n=4) and Sumf1A277V/A277V (A277V/A277V, n=4). Mean ± SEM are shown. Two-stage step-up (Benjamini, Krieger, and Yekutieli FDR procedure; *p < 0.05; **p < 0.01; ***p < 0.001.