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. 2024 Jan 11;80:101875. doi: 10.1016/j.molmet.2024.101875

Figure 2.

Figure 2

miR-15b-5p overexpression leads to changes on the proteome of a cardiomyocyte-like cell line. (A) Changes in protein levels in H9c2 cells transfected with miR-15b-5p mimic detected by MSMS. Coloured dots represent significantly regulated proteins (P < 0.05). (B-C) Canonical pathways' (B) and upstream regulators' (C) z-score, as predicted by IPA pathway enrichment analysis. (D) Cumulative fraction of fold change of putative targets predicted by TargetScan v7.1 in H9c2 cells transfected with a miR-15b-5p mimic compared to cells transfected with a negative control mimic. Statistical differences between distributions were calculated using two-sided Kolmogorov-Smirnov tests. (E) Z-score of protein levels in individual experiments with H9c2 cells transfected with a negative control or with a miR-15b-5p mimic. For A-E, negative control n = 3, miR-15b-5p mimic n = 3.