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Liver tissue from an A/JCr mouse at 9 months p.i. Periportal inflammation encloses the portal structures and extends into the surrounding hepatic parenchyma. The mixed mononuclear cell infiltrate is comprised of macrophages, lymphocytes, and plasma cells. Individual hepatocytes with karyomegaly (arrow) are present in mice with marked chronic hepatitis. Stain, hematoxylin and eosin. Bar, 100 μm.
