TABLE 2.

Hepatic and cecal lesion scores in control and H. hepaticus-infected mice^a

Mouse group and MO p.i.	n	Median lesion score (range)
		Liver				Cecum
		Parenchymal necrosis and inflammation	Portal inflammation	Sublobular phlebitis	Total score	Mucosal hyperplasia	Inflammation
Control
6	8	1 (0–1)	0 (0)	0 (0–2)	1 (0–3)	NDb	ND
9	6	0.5 (0–2)	0.5 (0–1)	0 (0–2)	1 (0–5)	ND	ND
12	6	1.5 (1–2)	1 (0–1)	0 (0–1)	2.5 (1–4)	2 (0–3)	2 (0–2)
Infected mice
6	5	2c (1–2)	0 (0–1)	0 (0–2)	2c (1–5)	ND	ND
9	6	1.5 (0–3)	1.5c (0–3)	2 (0–3)	5c (2–8)	ND	ND
12	6	2 (1–3)	1 (0–4)	2c (0–3)	4.5c (2–10)	2.5 (0–3)	3d (2–4)

^aMedian scores (see “Histologic evaluation” in Materials and Methods) for hepatic lesions were significantly higher in infected mice than in controls at 6, 9, and 12 months p.i. The scores for chronic cecal inflammation were significantly higher (P < 0.01) in the infected mice than in the controls at 12 months p.i. 

^bND, not done. 

^cP < 0.05, compared to value for control mice (by Mann-Whitney test). 

^dP < 0.01, compared to value for control mice (by Mann-Whitney test).