Fig. 1.

(A) Regional V_T values in individuals with AUD (n = 9; red circles) and healthy controls (n = 12; blue triangles). [¹⁸F]AS2471907 V_T is significantly higher in prefrontal-limbic brain regions in people with AUD vs. controls (*all ps < 0.05). AMY, amygdala; CAUD, caudate; HIPP, hippocampus; ACC, anterior cingulate cortex; VMPFC, ventromedial prefrontal cortex. (B) A representative participant's MRI (top panel), and co-registered parametric [¹⁸F]AS2471907 V_T image of a healthy control (middle panel) and an age- and sex-matched individual with AUD (bottom panel). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)