Figure 5.

Muscle hypertrophy driven by ActRII blockade is associated with improved exercise performance.

A) Example oxygen consumption trace from control animals during exercise performance protocol.

B) VO₂ max (mL/min) and time to exhausation (s) during VO₂ protocol.

C) Percent improvement in VO₂ max over the control group.

D) Percent improvement in time to exhaustion over the control group.

n = 4 mice for control, bimagrumab, semaglutide, semaglutide + bimagrumab groups. ∗p < 0.05 for control vs. bimagrumab, semaglutide, and semaglutide + bimagrumab.