Table 5.
Summary of findings: human studies treatment outcome
| Study | Disease | Species | Treatment duration (months) with BDQ | Treatment outcome | |||
|---|---|---|---|---|---|---|---|
| Culture conversion | Cure | Relapse | Symptom improvement | ||||
| Alexander et al. (2017)62 | Pulmonary | M. avium complex and M. intracellulare | ≥6 | 0/3 | 0/3 | 3/3 | 0/3 |
| Chan et al. (2021)63 | Extrapulmonary | M. abscessus | 8 | 1/1 | 1/1 | 0/1 | 1/1 |
| Erber et al. (2020)64 | Extrapulmonary | M. fortuitum complex | 3.5 | 1/1 | 1/1 | 0/1 | 1/1 |
| Gil et al. (2021)65 | Extrapulmonary disease | M. abscessus and M. avium | 21,14 | 2/2 | 2/2 | 0/2 | 2/2 |
| Meybeck et al. (2021)66 | A mix between extrapulmonary and pulmonary | M. marinum | 12 | 1/1 | 1/1 | 0/1 | 1/1 |
| Pearson et al. (2020)67 | Extrapulmonary | M. abscessus | > 3.5 | 1/1 | 1/1 | 0/1 | 1/1 |
| Philley et al. (2015)11 | Pulmonary | M. avium complex and M. intracellulare | 6 | 0/10 | 0/10 | 4/10 | 4/10 |
| Zweijpfenning et al. (2019)68 | Pulmonary | M. avium complex | ≥6 | 0/1 | 0/1 | N/A | 0/1 |
N/A, not applicable.