Table 2.
Key pharmacokinetic parameters of piperacillin in plasma (total concentrations) and microdialysate (free concentrations) after an IV infusion of 4.5 g piperacillin/tazobactam at steady-state conditions before and after albumin substitution
| Piperacillin (4 g) | Plasma before albumin (total concentration) | Plasma after albumin (total concentration) | MD before albumin (free concentration) | MD after albumin (free concentration) |
|---|---|---|---|---|
| C max (mg/L) | 229.11 (53.04) | 221.26 (65.44) | 158.10 (42.22) | 153.6 (102.48) |
| AUClast (hamg/L) | 402.08 (242.35) | 521.80 (363.01) | 398.94 (203.92) | 492.46 (510.815) |
| T max (h) | 0.5 | 0.5 | 0.68 (0.19) | 0.75 |
| t ½ (h) | 2.58 (1.87) | 2.77 (1.85) | 2.01 (1.8)a | 2.95 (2.16) |
| CL (L/h) | 11.75 (6.16) | 10.14 (6.76) | 12.55 (6.58)a | 12.44 (7.72) |
| V d (L) | 31.71 (9.16) | 27.09 (5.73) | 26.37 (10.11)a | 35.22 (14.03) |
Values are expressed as mean (SD).
aResults after exclusion of one outlier (n = 6).