Table 3.
Key pharmacokinetic parameters of tazobactam in plasma (total concentrations) and microdialysate (unbound concentrations) after an IV infusion of 4.5 g piperacillin/tazobactam at steady-state conditions before and after albumin substitution
| Tazobactam (0.5 g) | Plasma before albumin (total concentration) | Plasma after albumin (total concentration) | MDs before albumin (free concentration) | MD after albumin (free concentration) |
|---|---|---|---|---|
| C max (mg/L) | 25.84 (6.42) | 23.33 (4.72) | 19.47 (7.06) | 18.04 (12.21) |
| AUClast (hamg/L) | 53.16 (26.78) | 59.70 (31.63) | 54.48 (25.34) | 64.49 (64.40) |
| T max (h) | 0.5 | 0.5 | 0.75 | 0.75 |
| t ½ (h) | 2.70 (2.00) | 2.93 (1.92) | 2.34 (2.14)a | 3.21 (2.45) |
| CL (L/h) | 10.22 (5.35) | 9.19 (4.67) | 10.38 (4.76)a | 11.09 (6.31) |
| V d (L) | 28.89 (9.43) | 28.20 (3.97) | 25.12 (8.63)a | 34.89 (15.31) |
Values are expressed as mean (SD).
aResults after exclusion of one outlier (n = 6).