Table 2.

Pattern of results in the 10 different disorder pairings examined in this paper

Pair #/Figure	Class of pair	Disorder A	Disorder B	Population ORs between the two disorders	Number of comparisons significantly greater in comorbid cases	Number significantly less in comorbid cases	FGRS for disorder A sig greater in comorbid than in disorder A only cases	FGRS for disorder B sig greater in comorbid than in disorder B only cases	Other FGRS substantially greater in comorbid v. A-only cases	Other FGRS substantially greater in comorbid v. B-only cases
1/1a	Closely related disorders	MD	AD	11.2 (11.1; 11.3)	15/16	0	Yes	Yes	AD, DUD, AUD	MD, DUD, ADHD
2/1b		AUD	DUD	18.9 (18.7; 19.1)	16/16	0	Yes	Yes	DUD, ADHD, AD	AUD, ADHD, AD
3/1c		ADHD	ASD	15.9 (15.5; 16.3)	9/16	3	No	Yes	ASD, SZ, MD	ADHD, DUD,AUD
4/1d		AD	OCD	12.7 (12.4; 13.0)	13/18	1	Yes	No	OCD, MD, ASD	AD, MD, AUD
5/1e		DUD	ADHD	11.0 (10.8; 11.1)	15/16	1	Yes	Yes	ADHD, DUD, AUD	DUD, AUD, AD
6/2a	Moderately related disorders	MD	AUD	2.9 (2.9; 2.9)	15/16	0	Yes	Yes	AUD, DUD, ADHD	MD, AD, ADHD
7/2b		AD	SZ	2.3 (2.3; 2.4)	10/16	0	No	No	SZ, ASD, DUD	AD, DUD, MD.
8/2c		MD	ASD	3.5 (3.4; 3.5)	11/16	2	Yes	Yes	ASD, ADHD, SZ	MD, AD, ADHD
9/2d		DUD	SZ	9.0 (8.7; 9.3)	8/16	4	No	No	SZ, ASD, BD	DUD, AUD, AD
10/2e		AUD	BD	5.0 (4.9; 5.0)	12/16	1	No	No	BD, AD, MD	AUD, DUD, ADHD

Int − Internalizing; Ext – Externalizing. MD − major depression, AD − anxiety disorders, AUD − alcohol use disorder, DUD − drug use disorder, ADHD − attention deficit-hyperactivity disorder, ASD − autism spectrum disorder, OCD – obsessive −compulsive disorder, SZ − schizophrenia, and BD − bipolar disorder. Sig −– significantly.