Table 1.

Criteria for toxic effects in cats receiving doxorubicin (Rassnick et al 2000)

Toxicity and grade	Criteria
Neutropenia
0	None
1	1500–3000 neutrophils/μl
2	1000–1500 neutrophils/μl
3	500–1000 neutrophils/μl
4	<500 neutrophils/μl
Renal
0	None
1	Creatinine 1.5–3 mg/dl
2	Creatinine 3–4 mg/dl
3	Creatinine 4–5 mg/dl
4	Creatinine >5 mg/dl
Anorexia
0	None
1	Inappetence
2	Anorexia<3 days duration
3	Anorexia>3 days but <5 days duration
4	Anorexia>5 days duration; 10% weight loss
Vomiting
0	None
1	Nausea
2	Sporadic, self-limiting
3	1/5 Episodes per day, <2 days
4	6–10 Episodes per day, requires hospitalization
Diarrhea
0	None
1	Soft stools, responds to dietary modification
2	1–4 Watery stools per day, <2 days
3	4–7 Watery stools per day, or >2 days
4	>7 Watery stools per day or bloody, requires hospitalization