Fig 1.

Effects of injection of IL-2 CLDC on body temperature in healthy cats. Six healthy, 6–8-month-old purpose-bred cats were randomized into two treatment groups of three cats each (group 1). One subgroup of three cats was injected intraperitoneally once weekly with liposome–DNA complexes (CLDC) containing 150 μg plasmid DNA encoding the feline IL-2 cDNA (IL-2 CLDC group). A second subgroup of three cats was injected intraperitoneally with saline only (control). Body temperature was assessed before treatment and at 2–4-h intervals after injection for a 24-h period. The mean body temperature (±SD) for each group was plotted. Body temperature increased significantly (P<0.05) in the IL-2 CLDC group beginning 6 h after injection and remained significantly elevated for a 24-h period.