Table 2.

C/D at T3 and in cord blood, transplacental passage index

Drug	T3 daily dose	T3 mother blood concentrations	Mother C/D	Cord blood concentrations	Infant C/D	PPI
Sertraline	72.67 ± 36.52 (25–200)	27.04 ± 22.75 (2.5–90.7)	0.35 ± 0.22 (0.03–0.85)	7.89 ± 7.80 (2.5–35.5)	0.11 ± 0.1 (0.0–0.38)	0.43 ± 0.26 (0.06–1)
Paroxetine	18.08 ± 4.08 (10–25)	14.17 ± 16.05 (2.5–41.9)	1.08 ± 1.58 (0.13–4.19)	3.61 ± 2.95 (2.5–10.3)	0.22 ± 0.14 (0.13–0.52)	0.76 ± 0.41 (0.08–1)
Escitalopram	10.64 ± 5.42 (5–20)	18.89 ± 21.33 (2.5–68.8)	1.87 ± 2.19 (0.25–6.88)	8.7 ± 6.75 (2.5–15.9)	1.13 ± 0.76 (0.25–1.59)	0.78 ± 0.26 (0.49–1)
Citalopram	20 ± 0.00 (20–20)	49 ± 38.15 (14.9–90.2)	2.45 ± 1.9 (0.75–4.51)	(*) 5.5	(*) 0.28	(*) 0.60
Fluoxetine	22.50 ± 5.00 (20–30)	(*) 346.8	(*) 11.56	87.70 ± 76.91 (2.5–152)	4.39 ± 3.84 (0.13–7.60)	0.71 ± 0.5 (0.13–1)
Venlafaxine	95.46 ± 35.02 (75–150)	146.12 ± 86.68 (37.6–260.1)	1.73 ± 1.03 (0.33–3.27)	154.54 ± 67.46 (78.9–234.7)	1.64 ± 0.84 (0.53–2.46)	0.77 ± 0.23 (0.40–0.98)
Duloxetine	45.0 ± 21.21 (30–60)	(*) 11.2	(*) 0.37	//	//	//

Drug daily dose expressed as mg/die; blood concentrations expressed as ng/mL; the table shows means concentrations ± SD (min-max); C/D: concentration per dosage = ng/mL: mg/die.

PPI was assessed by dividing the C/D in the cord blood per the C/D at T3 and T4 in the women’s peripheral blood samples.

PPI, placental passage index.