Table 3.
Association by study between apoB, LDL-C/apoB with CHD outcomes, per 1 SD increments adjusting for standard risk factors.
| UKB | WHS | FHS | ||||
|---|---|---|---|---|---|---|
| Variable | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value |
| Sex (male) | 1.96 (1.89, 2.04) | <0.001 | — | — | 2.28 (1.64, 3.17) | <0.001 |
| Age (per year) | 1.07 (1.06, 1.07) | <0.001 | 1.09 (1.08, 1.10) | <0.001 | 1.05 (1.03, 1.07) | <0.001 |
| ApoB | 1.24 (1.22, 1.27) | <0.001 | 1.33 (1.20, 1.47) | <0.001 | 1.24 (1.09, 1.42) | 0.002 |
| LDL-C/ApoB | 1.00 (0.98, 1.02) | 0.842 | 0.97 (0.87, 1.08) | 0.540 | 0.78 (0.64, 0.94) | 0.010 |
| HDL-C | 0.79 (0.77, 0.81) | <0.001 | 0.90 (0.81, 1.01) | 0.061 | 0.79 (0.65, 0.97) | 0.022 |
| Systolic Blood Pressure | 1.19 (1.17, 1.21) | <0.001 | 1.35 (1.23, 1.48) | <0.001 | 1.17 (1.01, 1.36) | 0.037 |
| Blood pressure-lowering medications | 1.53 (1.47, 1.59) | <0.001 | 1.19 (0.93, 1.51) | 0.160 | 1.17a (0.84, 1.63) | 0.361 |
| Diabetes | 2.04 (1.87, 2.23) | <0.001 | 4.23 (3.08, 5.82) | <0.001 | 2.53 (1.70, 3.76) | <0.001 |
| Smoking | 1.22 (1.18, 1.26) | <0.001 | 1.77 (1.47, 2.13) | <0.001 | 1.49 (1.09, 2.05) | 0.014 |
Estimates for ApoB, LDL-C/ApoB, HDL-C, and systolic blood pressure are expressed per 1 SD.