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. 2024 Jan 23;3(2):pgae023. doi: 10.1093/pnasnexus/pgae023

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© The Author(s) 2024. Published by Oxford University Press on behalf of National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5. — Drug-stimulation time-dependent response in plasma EVs. A) Volcano plot highlighting comparative ADME response to rifampicin treatment on day 7. Among various ADME proteins, Cyp3a11 and Ugt2a3 in plasma EVs emerged with the most consistent and significant induction (FDR < 0.05), from three pairs of biological replicates. Response of B) Cyp3a11 and C) Ugt2a3, respectively, to rifampicin along 7-day treatment was illustrated individually and P-values of treatment response were plotted at designated positions.