Table 1:
Summary of aneuploidy and CIN results in brain of mice and rats.
| AUTHOR | YEAR | SPECIES | TECHNIQUE | PROBES | CASES (N) | AGE | TISSUE | CELL TYPE | NUMBER OF NUCLEI | DETECTION METRIC | AREA RESULT | CHROMOSOME | CHR AFFECTED % | AVERAGE CHR % | % PER TISSUE | NOTES | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| REHEN 5 | 2001 | Mo (BALB/c) | SKY-FISH | Chr X/Y | unk | E11-14-adult | Cortex | Mitotic neuroblasts and post mitotic bulk | 220 (SKY) 300 (FISH) | Aneuploidy | Embryonic | Y | 1–5.9 | unk | 33 | ||
| Embryonic | X | 2.1 | unk | ||||||||||||||
| KAUSHAL 6 | 2003 | Mo (GFP transgenic) | SKY-FISH | Chr X/Y | 65 | P5-P10 | SVZ and OB | NPCs (SKY) bulk (FISH) | 65 (SKY) unk (FISH) | Aneuploidy | SVZ | X/Y | 5 | unk | 33 | ||
| OB | X/Y | 6 | unk | ||||||||||||||
| YANG 7 | 2003 | Mo (BALB/c) | SKY | n/a | unk | E11-14 | Cortex | Mitotic NPC | 220 | Aneuploidy | NPC | all | unk | unk | 33.2 | ||
| KINGSBURY 8 | 2005 | Mo (BALB/c) | FISH and paint | Chr X/Y | 10 | 10 wks | Whole brain | Neurons | 1000 | Hyperdiploidy | X/Y | 0.2 | unk | unk | |||
| WESTRA 9 | 2008 | Mo (BALB/c) | FISH and M-FISH | Chr 16/X | unk | P0, P7 and adult | Cerebellum | Mitotic NPCs, neurons, and non-neurons | >18,000 | Aneuploidy | X | 1.1 | 1 | 20 | P0 (15.3) | ||
| 16 | 1.6 | 1 | P7 (20.8) | ||||||||||||||
| FAGGIOLI 10 | Mo (C57B6) | FISH-dual | Chr 1/7/14/15/6/18/19/Y | 21 | 4–28 mo. | Cortex and cerebellum | NeuN and NeuN-neg | >10,000 | Aneuploidy | Cerebellum | 1/7/14/15/6/18/19/Y | 0.7–1.6 | 1.2–9.8 | up to 30 | 28 mo significantly increased vs. 4 mo | ||
| Cortex | 1/7/14/15/6/18/19/Y | <1 | <1 | ||||||||||||||
| KNOUSE 11 | 2014 | Mo (Nestin-GFP mice, C57BL/6) | sc-WGS | n/a | unk | Embryonic and adult | Cerebral Cortex | Bulk, neuron/non (NeuN) | 43 nuclei and 19 nuclei | Aneuploidy | Embryonic | 15 | 2.3 | unk | 1 | ||
| Adult | na | 0 | 0 | ||||||||||||||
| ANDRIANI 12 | 2016 | Mo (Ercc1−/Δ7 and Bub1bH/H) | FISH-dual | Chr 1/7/18 | 18 | E13.5-6 mo | Cerebral cortex and cerebellum | Bulk | 1000–1500 | Aneuploidy | Embryonic | 1/18 | 2.3–37.7 | variable | 30 | ||
| Adult | <1 | <1 | |||||||||||||||
| PETERSON 13 | 2012 | Mo (C57B6) | SKY and FISH | Chr 8/16 | unk | E19 | Cerebral Cortex | Mitotic NPS and post mitotic bulk | 100 (SKY) 2500–3500 (FISH) | Aneuploidy | E19 | 16 | 2.1 | unk | 24–29 | ||
| 8 | 1.6 | unk | |||||||||||||||
| NING 14 | 2015 | rat | sc-WGS | n/a | 2 | E18 | Hippocampus | NeuN | 19 | CNV | 8 | unk | unk | unk | large scale CNV detected | ||