TABLE 3.

Mixed-Effect Model for Vasopressor Requirement^a

	Initial Model		Final Model
Predictors	Coefficient	p	Coefficient	p
Day of therapy	−0.001	< 0.0001	−0.002	0.0002
Current day Sequential Organ Failure Assessment	0.008	< 0.0001	−0.007	< 0.0001
Fludrocortisoneb	0.159	0.0055	—	—
Hydrocortisoneb	0.0004	< 0.0001	0.0003	< 0.0001
Renal replacement therapyc	0.020	< 0.0001	—	—
Type of infectiond	−0.004	0.24	—	—
100% T>MICc	—	—	−0.006	0.0318
100% T>4×MICc	—	—	0.002	0.38

T_>MIC and T_>4×MIC = time the free beta-lactam concentration was above the minimum inhibitory concentration or four multiples of the minimum inhibitory concentration, respectively.

^aVasopressors requirement was evaluated as norepinephrine-equivalent dose based on µg/kg/min.

^bPer 1 mg/d.

^cYes compared with no.

^dBlood vs. pneumonia.Values in boldface font are p < 0.05.