Table 1.

SVD CADMUS Phenotype Criteria

	Main classification
CAA	Boston criteria 2.0 Supratentorial lobar ICH or nonaneurysmatic, cSAH AND ≥1 of the following:  • ≥1 additional, supratentorial lobar, cortical or subcortical hemorrhagic lesion (ICH, CMB, cSS/cSAH distant to the index ICH)  • >20 CSO-PVSs per hemisphere  • Multispot white matter hyperintensity pattern
Mixed CAA-DPA	Concomitant presence of characteristic features for CAA and DPA Deep supratentorial or brainstem ICH AND ≥1 of the following:  • ≥1 additional, supratentorial lobar, cortical or subcortical hemorrhagic lesion (ICH, CMB, cSS/cSAH distant to the index ICH)  • >20 CSO-PVSs per hemisphere  • Multispot white matter hyperintensity pattern OR Lobar supratentorial or nonaneurysmatic, cSAH AND ≥1 of the following:  • ≥1 additional, deep supratentorial or brainstem hemorrhagic lesion (ICH, CMB)  • ≥1 deep supratentorial or brainstem lacune  • Periventricular white matter lesions Fazekas grade ≥2 Additional SVD features can be present
DPA	Deep supratentorial or brainstem ICH AND ≥1 of the following:  • ≥1 additional, deep supratentorial or brainstem hemorrhagic lesion (ICH, CMB)  • ≥1 deep supratentorial or brainstem lacune  • Periventricular white matter lesions Fazekas grade ≥2 Additional SVD features can be present
Undetermined SVD	ICH of any location AND Signs of SVD not fulfilling the criteria for CAA, DPA or mixed CAA-DPA, e.g. ≥1 of the following:  • ≥1 lobar or cerebellar lacune  • >20 BG-PVS per hemisphere  • Periventricular white matter lesions Fazekas grade 1 or any isolated, deep white matter lesions  • Recent, small infarcts OR Cerebellar or holohemispheric ICH or uncertain hematoma epicenter AND ≥1 of the following:  • ≥1 additional, deep supratentorial or brainstem hemorrhagic lesion (ICH, CMB)  • ≥1 deep supratentorial or brainstem lacune  • Periventricular white matter lesions Fazekas grade ≥2  • ≥1 additional, supratentorial lobar, cortical or subcortical hemorrhagic lesion (ICH, CMB, cSS/cSAH distant to the index ICH) Additional SVD features can be present

Abbreviations: BG = basal ganglia; CAA = cerebral amyloid angiopathy; CMB = cerebral microbleed; CSO = centrum semiovale; cSAH = convexity subarachnoid hemorrhage; cSS = cortical superficial siderosis; DPA = deep perforator arteriopathy; ICH = intracerebral hemorrhage; PVS = perivascular space; SVD = small vessel disease.