Table 2.
Baseline Table
| All ICH | ||||||
| Total (N = 1,180, 100%) | CAA (N = 154, 13.1%) | DPA (N = 72, 6.3%) | Mixed CAA-DPA (N = 751, 63.6%) | Undetermined (N = 203, 17.2%) | p Value | |
| Demographics | ||||||
| Age, y, median (IQR) | 73 (62–80) | 73 (65–79) | 72 (61–79) | 74 (64–80) | 68 (56–78) | <0.001 |
| Sex, female, n (%) | 492 (44.5) | 69 (49.6) | 24 (35.3) | 323 (45.4) | 76 (40.9) | 0.17 |
| Cerebrovascular risk factors, n (%) | ||||||
| Hypertension | 797 (76.9) | 80 (62.5) | 54 (79.4) | 529 (79.4) | 134 (76.6) | <0.001 |
| Diabetes mellitus | 160 (16.4) | 16 (13.8) | 10 (15.9) | 109 (17.0) | 25 (15.7) | 0.84 |
| Hyperlipidemia (treatment or LDL >2.6 mmol/L) | 500 (50.9) | 55 (46.2) | 35 (55.6) | 336 (52.7) | 74 (45.4) | 0.22 |
| Actively smoking (or stopped <2 y ago) | 129 (14.6) | 16 (15.0) | 3 (5.6) | 83 (14.6) | 27 (17.9) | 0.18 |
| Atrial fibrillation (>1 documented episode) | 148 (14.3) | 18 (14.2) | 13 (19.1) | 96 (14.5) | 21 (12.1) | 0.57 |
| History of intracranial hemorrhage | 118 (11.4) | 17 (13.4) | 3 (4.4) | 83 (12.5) | 15 (8.6) | 0.12 |
| History of ischemic stroke or retinal infarction | 110 (10.6) | 10 (7.9) | 8 (11.8) | 69 (10.4) | 23 (13.1) | 0.52 |
| Antiplatelets on admission | 295 (27.8) | 39 (29.3) | 17 (25.4) | 197 (28.6) | 42 (24.0) | 0.60 |
| Anticoagulation on admission | 184 (17.2) | 22 (16.4) | 11 (16.2) | 118 (17.1) | 33 (18.6) | 0.95 |
| Clinical presentation on admission | ||||||
| Systolic blood pressure on admission, median (IQR) | 166 (145–185) | 153 (138–170.5) | 177 (160–190) | 168 (147–189) | 165 (140–183) | <0.001 |
| Diastolic blood pressure on admission, median (IQR) | 89 (78–101) | 83 (70–90) | 92 (84–110) | 90 (80–104) | 90 (78–104) | <0.001 |
| NIHSS on admission, median (IQR) | 6 (2–12) | 4 (1–11) | 9 (5–14) | 6 (3–12) | 4.5 (1–11.5) | <0.001 |
| GCS on admission, median (IQR) | 15 (14–15) | 15 (14–15) | 15 (14–15) | 15 (14–15) | 15 (13–15) | 0.57 |
| Hematoma epicenter, n (%) | <0.001 | |||||
| Deep | 439 (37.2) | 0 (0.0) | 65 (90.3) | 347 (46.2) | 27 (13.3) | |
| Lobar | 538 (45.6) | 139 (90.3) | 0 (0.0) | 362 (48.2) | 37 (18.2) | |
| Brainstem | 40 (3.4) | 0 (0.0) | 7 (9.7) | 28 (3.7) | 5 (2.5) | |
| Cerebellum | 73 (6.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 73 (36.0) | |
| Isolated IVH | 11 (0.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 11 (5.4) | |
| Isolated cSAH | 33 (2.8) | 15 (9.7) | 0 (0.0) | 14 (1.9) | 4 (2.0) | |
| Undetermined | 46 (3.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 46 (22.7) | |
| SMASH-U, n (%) | <0.001 | |||||
| Hypertension | 538 (45.6) | 23 (14.9) | 54 (75.0) | 365 (48.6) | 96 (47.3) | |
| Antithrombotic | 68 (5.8) | 12 (7.8) | 1 (1.4) | 47 (6.3) | 8 (3.9) | |
| CAA | 152 (12.9) | 32 (20.8) | 0 (0.0) | 105 (14.0) | 15 (7.4) | |
| Unknown | 290 (24.6) | 63 (40.9) | 14 (19.4) | 155 (20.6) | 58 (28.6) | |
| Missing information | 132 (11.2) | 24 (15.6) | 3 (4.2) | 79 (10.5) | 26 (12.8) | |
| Outcomes (per 100 patient-years), median (IQR) | ||||||
| Any event | 58.5 (50.0–68.6) | 51.3 (32.3–81.3) | 57.4 (29.9–110.3) | 52.40 (42.6–64.5) | 89.6 (65.2–123.1) | |
| Ischemic stroke | 11.0 (7.7–15.9) | 2.9 (0.4–20.2) | 12.8 (3.2–51.0) | 10.0 (6.2–16.1) | 21.2 (11.0–40.8) | |
| ICH | 10.6 (7.3–15.4) | 17.1 (7.7–38.0) | 0 | 8.8 (5.3–14.6) | 16.5 (7.9–34.6) | |
| Death | 43.71 (36.4–52.5) | 39.9 (23.6–67.3) | 44.6 (21.3–93.7) | 39.4 (31.0–50.1) | 63.6 (43.6–92.8) | |
Abbreviations: CAA = cerebral amyloid angiopathy; cSAH = convexity subarachnoid hemorrhage; DPA = deep perforator arteriopathy; DOAC = direct oral anticoagulant; GCS = Glasgow Coma Scale; ICH = intracerebral hemorrhage; IQR = interquartile range; IVH = intraventricular hemorrhage; LDL = low-density lipoprotein; NIHSS = NIH Stroke Scale; SVD = small vessel disease.