Table 1.
Clinical characteristics of participants in the microbiome cohort
| Characteristics | ALS group (n = 75) | Control group (n = 110) | P-value |
|---|---|---|---|
| Age, yearsa | 65.7 ± 10.0 (36.3–84.8) | 62.0 ± 8.6 (38.81–86.26) | 0.010b |
| Sex | – | – | |
| Male | 43 (57.3%) | 44 (40.0%) | 0.025c |
| Female | 32 (42.7%) | 66 (60.0%) | |
| Family history of ALS | – | – | |
| Yes | 7 (9.3%) | 0 (0%) | |
| No | 67 (89.3%) | 110 (100.0%) | |
| Unknown | 1 (1.3%) | 0 (0%) | |
| Race | – | – | |
| White | 75 (100.0%) | 110 (100.0%) | |
| ALS with frontotemporal dementia | 1 (1.33%) | – | |
| Onset segment | – | – | |
| Bulbar | 25 (33.3%) | – | |
| Cervical | 24 (32.0%) | – | |
| Lumbar | 24 (32.0%) | – | |
| Respiratory | 2 (2.67%) | – | |
| El Escorial criteria | – | – | |
| Definite | 16 (21.6%) | – | |
| Probable | 30 (40.5%) | – | |
| Probable, lab supported | 17 (23.0%) | – | |
| Possible | 9 (12.2%) | – | |
| Suspected | 2 (2.70%) | – | |
| Missing | 1 (1%) | – | |
| ALS Functional Rating Scale-Revisedd | 37.0 (34.0–40.0) | – | |
| Days from symptom onset to diagnosisd | 343.0 (216.5–617.5) | – | |
| Feeding tube | – | – | |
| Yes | 6 (8.0%) | – | |
| No | 69 (92.0%) | – | |
| Days from diagnosis to stool sampled | 98.0 (39.5–191.5) | – |
Bold font indicates significant P-values.ALS = amyotrophic lateral sclerosis.
aMean ± standard deviation (range).
bStudent’s t-test.
cFisher’s exact test.
dMedian (interquartile range).