Table 2.

VBM statistical details: neural correlates of impaired motor speech

Brain region	Peak MNI coordinates			Voxel-level inference		Cluster-level inference
	x	y	z	t-value	P-value (unc)	Extent	P-value (FWE-corr)
VBM Analysis 1: apraxia of speech (controlling for dysarthria)
LPut	−32	−14	0	4.91	0.000	5462a	0.003
LWM/LPut	−27	18	3	4.32	0.000
LPut	−27	3	−9	4.18	0.000
LWM/LPut	−18	12	−14	3.97	0.000
LFO/LadIns	−38	20	3	3.45	0.000
LpOp/LvPMC	−48	9	16	3.37	0.001
LWM/LPut	−30	−3	9	3.33	0.001
LadIns/LFO	−44	8	−2	2.78	0.003
VBM Analysis 1: dysarthria (controlling for apraxia of speech)
RvPreCG	57	2	26	5.89	0.000	13578a	0.000
RWM/RdPreCG	36	−12	57	4.83	0.000
RWM/RdPreCG	12	−14	60	4.44	0.000
RWM/RdPreCG	16	−12	60	4.43	0.000
RvPreCG	42	−8	36	4.43	0.000
RWM/RvPreCG	44	−8	40	4.42	0.000
RvPostCG	56	−8	42	4.32	0.000
RWM/RmCS	15	−9	46	3.82	0.000
RavSMG/RPO	54	−26	16	3.72	0.000
CC	8	−12	24	3.61	0.000
RWM	18	−8	34	3.45	0.000
RmCS/RmCG	9	4	40	3.18	0.001
LWM/LdPreCG	−28	−15	52	3.91	0.000	3452a	0.025
LWM/LdPreCG	−15	−20	62	3.89	0.000
LWM/LdPreCG	−34	−12	56	3.84	0.000
LWM/LdPreCG	−14	−3	58	3.45	0.000

The table lists representative peak voxels. ad = anterodorsal; CC = corpus callosum; CG = cingulate gyrus; CS = cingulate sulcus; d = dorsal; FO = frontal operculum; FWE-corr = family-wise error corrected; Ins = insula; L = left; m = mid; MNI = Montreal Neurological Institute space; PMC = premotor cortex; PO = parietal operculum; pOp = pars opercularis; PostCG = postcentral gyrus; PreCG = precentral gyrus; Put = putamen; R = right; SMG = supramarginal gyrus; unc = uncorrected; v = ventral; VBM = voxel-based morphometry; WM = white matter.

^aUsing a cluster-forming voxelwise threshold of P < 0.005 uncorrected.