Table 1.
List of clinical trials on clinicaltrials.gov investigating the delivery of extracellular vesicles for the treatment of brain diseases
| NCT Number | Source | Conditions | Phase | Country | Status |
|---|---|---|---|---|---|
| NCT03384433 | Allogenic MSC-derived EVs transfected with miR-124 | Ischaemic stroke | 1/2 | Iran | Passed completion date |
| NCT04202770 | Amniotic fluid EVs | Dementia, depression, anxiety | 1 | USA | Suspended (pending COVID-19 pandemic) |
| NCT04202783 | EVs (not further specified) | Craniofacial neuralgia | 1 | USA | Suspended (pending COVID-19 pandemic) |
| NCT04388982 | Allogenic adipose MSC-derived EVs | Alzheimer's disease | 1/2 | China | Passed completion date |
| NCT05490173 | MSC-derived EVs | Neurodevelopmental disorders of prematurity | 1 | Russia | Not yet recruiting |
COVID-19 = coronavirus disease 2019; EV = extracellular vesicle; MSC = mesenchymal stromal cell; NCT = National Clinical Trial.