Fig. 5.
Representative images depicting biodistribution pattern of single i.v. administered transduced hUC-MSCs (18.5 × 106 cells/kg BW) in healthy BALB/c mice at designated time points (1 h, 24 h, 2, 3, 4 days after cell administration). (a) Transduced hUC-MSCs migrated and localised to lungs as early as 1 h post-administration. The signal remained in lungs for up to 3 days before being cleared from the body. (b) Bioluminescence intensity quantification of the whole body of mice at designated time points. (c) Average percentage of signal intensity in lungs at designated time points. Data are presented as mean ± SEM (n = 5).