Table 2.
Differentially expressed proteins in gastric tumor tissues with tandem mass tag (TMT) system.
| Protein Name | Gene Name | Fold Change | Expression |
|---|---|---|---|
| ADP-ribosylation factor | ARF | 1.74 | upregulated |
| E3 ubiquitin-protein ligase Mdm2 | MDM2 | 1.71 | upregulated |
| Protein kish-B | TMEM167B | 1.65 | upregulated |
| Transgelin | TAGLN | 1.56 | upregulated |
| Transcription factor BTF3 homolog 4 | BTF3L4 | 1.52 | upregulated |
| X antigen family member 2 | XAGE2 | 1.50 | upregulated |
| RISC-loading complex subunit TARBP2 | TARBP2 | 1.50 | upregulated |
| Sodium-coupled neutral amino acid transporter 2 | SLC38A2 | 1.38 | upregulated |
| Cationic amino acid transporter 2 | SLC7A2 | 1.35 | upregulated |
| Asparagine synthetase [glutamine-hydrolyzing] | ASNS | 1.34 | upregulated |
| Zinc transporter ZIP1 | SLC39A1 | 1.33 | upregulated |
| Anthrax toxin receptor 1 | ANTXR1 | 1.33 | upregulated |
| Nexilin | NEXN | 1.32 | upregulated |
| Reticulophagy regulator 2 | RETREG2 | 1.32 | upregulated |
| Protein disulfide-isomerase TMX3 | TMX3 | 1.31 | upregulated |
| Allograft inflammatory factor 1-like | AIF1L | 1.31 | upregulated |
| Putative ATP-dependent RNA helicase DHX57 | DHX57 | 1.29 | upregulated |
| Cystine/glutamate transporter | SLC7A11 | 1.28 | upregulated |
| Acyl-CoA desaturase | SCD | 1.28 | upregulated |
| UPF0711 protein C18orf21 | C18orf21 | 1.27 | upregulated |
| Synaptosomal-associated protein 25 | SNAP25 | 1.27 | upregulated |
| Protein tweety homolog 3 | TTYH3 | 1.27 | upregulated |
| Neugrin | NGRN | 1.27 | upregulated |
| Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial | MMAB | 1.27 | upregulated |
| Caldesmon | CALD1 | 1.26 | upregulated |
| Transmembrane protein 179B | TMEM179B | 1.26 | upregulated |
| Beta-arrestin-2 | ARRB2 | 1.26 | upregulated |
| 28S ribosomal protein S33, mitochondrial | MRPS33 | 1.26 | upregulated |
| Mitochondrial mRNA pseudouridine synthase RPUSD3 | RPUSD3 | 1.26 | upregulated |
| Centrosomal protein of 126 kDa | CEP126 | 1.25 | upregulated |
| Mitochondrial mRNA pseudouridine synthase TRUB2 | TRUB2 | 1.24 | upregulated |
| Nucleolus and neural progenitor protein | NEPRO | 1.23 | upregulated |
| Plastin-1 | PLS1 | 1.22 | upregulated |
| Fatty acyl-CoA reductase 1 | FAR1 | 1.21 | upregulated |
| ATP-binding cassette sub-family D member 3 | ABCD3 | 1.21 | upregulated |
| Dolichyl-phosphate beta-glucosyltransferase | ALG5 | 1.21 | upregulated |
| Low-density lipoprotein receptor | LDLR | 1.21 | upregulated |
| Ribonuclease P protein subunit p25 | RPP25 | 1.21 | upregulated |
| CD63 antigen | CD63 | 1.21 | upregulated |
| Receptor-type tyrosine-protein phosphatase S | PTPRS | 1.21 | upregulated |
| Krueppel-like factor 16 | KLF16 | 1.20 | upregulated |
| Mitochondrial import receptor subunit TOM5 homolog | TOM5 | 1.20 | upregulated |
| Tripartite motif-containing protein 26 | TRIM26 | 1.20 | upregulated |
| Peroxiredoxin-2 | PRDX2 | 0.83 | downregulated |
| Zinc transporter ZIP6 | SLC39A6 | 0.83 | downregulated |
| Protein S100-A14 | S100A14 | 0.83 | downregulated |
| Ral GTPase-activating protein subunit alpha-1 | RALGAPA1 | 0.83 | downregulated |
| Rab-like protein 3 | RABL3 | 0.83 | downregulated |
| Transcription elongation factor SPT4 | SUPT4H1 | 0.83 | downregulated |
| Serine/threonine-protein kinase SMG1 | SMG1 | 0.83 | downregulated |
| Sugar phosphate exchanger 3 | SLC37A3 | 0.83 | downregulated |
| Dipeptidyl peptidase 1 | CTSC | 0.83 | downregulated |
| Serum paraoxonase/arylesterase 2 | PON2 | 0.83 | downregulated |
| Macrophage-stimulating protein receptor | MST1R | 0.83 | downregulated |
| Gelsolin | GSN | 0.83 | downregulated |
| Coiled-coil domain-containing protein 186 | CCDC186 | 0.83 | downregulated |
| DBF4-type zinc finger-containing protein 2 | ZDBF2 | 0.83 | downregulated |
| 2′-5′-oligoadenylate synthase-like protein | OASL | 0.83 | downregulated |
| Calcium-regulated heat-stable protein 1 | CARHSP1 | 0.83 | downregulated |
| Probable imidazolonepropionase | AMDHD1 | 0.82 | downregulated |
| ALS2 C-terminal-like protein | ALS2CL | 0.82 | downregulated |
| Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A | MGAT5 | 0.82 | downregulated |
| Alpha-N-acetylgalactosaminidase | NAGA | 0.82 | downregulated |
| Aminoacylase-1 | ACY1 | 0.82 | downregulated |
| Coagulation factor V | F5 | 0.82 | downregulated |
| Tuftelin | TUFT1 | 0.82 | downregulated |
| Deuterosome assembly protein 1 | DEUP1 | 0.82 | downregulated |
| Kinesin light chain 4 | KLC4 | 0.82 | downregulated |
| RELT-like protein 1 | RELL1 | 0.82 | downregulated |
| Complement factor H | CFH | 0.82 | downregulated |
| Phosducin-like protein | PDCL | 0.82 | downregulated |
| Carbonic anhydrase 9 | CA9 | 0.82 | downregulated |
| Fibrinogen alpha chain | FGA | 0.82 | downregulated |
| Hydroxyacid oxidase 2 | HAO2 | 0.82 | downregulated |
| CD109 antigen | CD109 | 0.82 | downregulated |
| Cysteine-rich protein 2 | CRIP2 | 0.81 | downregulated |
| Annexin A2 | ANXA2 | 0.81 | downregulated |
| Methionine synthase | MTR | 0.81 | downregulated |
| Uncharacterized protein NCBP2-AS2 | NCBP2-AS2 | 0.81 | downregulated |
| ERO1-like protein alpha | ERO1A | 0.81 | downregulated |
| Sjoegren syndrome/scleroderma autoantigen 1 | SSSCA1 | 0.81 | downregulated |
| Breast cancer metastasis-suppressor 1 | BRMS1 | 0.81 | downregulated |
| Leucine-rich repeat and coiled-coil domain-containing protein 1 | LRRCC1 | 0.81 | downregulated |
| Dynein heavy chain 12, axonemal | DNAH12 | 0.81 | downregulated |
| BTB/POZ domain-containing protein KCTD3 | KCTD3 | 0.81 | downregulated |
| Thrombospondin type-1 domain-containing protein 7B | THSD7B | 0.81 | downregulated |
| E3 ubiquitin-protein ligase Hakai | CBLL1 | 0.81 | downregulated |
| Apolipoprotein E | APOE | 0.81 | downregulated |
| Antithrombin-III | SERPINC1 | 0.81 | downregulated |
| Myristoylated alanine-rich C-kinase substrate | MARCKS | 0.81 | downregulated |
| G-protein-signaling modulator 1 | GPSM1 | 0.81 | downregulated |
| Membrane-spanning 4-domains subfamily A member 14 | MS4A14 | 0.80 | downregulated |
| Zinc finger protein 512 | ZNF512 | 0.80 | downregulated |
| F-box only protein 50 | NCCRP1 | 0.80 | downregulated |
| Myosin-10 | MYH10 | 0.80 | downregulated |
| Ribonucleoside-diphosphate reductase subunit M2 B | RRM2B | 0.80 | downregulated |
| Butyrophilin subfamily 3 member A1 | BTN3A1 | 0.80 | downregulated |
| Annexin A9 | ANXA9 | 0.80 | downregulated |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | EBP | 0.80 | downregulated |
| Bax inhibitor 1 | TMBIM6 | 0.80 | downregulated |
| Beta-synuclein | SNCB | 0.80 | downregulated |
| Cocaine esterase | CES2 | 0.80 | downregulated |
| Mitogen-activated protein kinase 8 | MAPK8 | 0.80 | downregulated |
| Membrane cofactor protein | CD46 | 0.80 | downregulated |
| Protein ABHD14B | ABHD14B | 0.79 | downregulated |
| Protein FAM177A1 | FAM177A1 | 0.79 | downregulated |
| Protein TANC1 | TANC1 | 0.79 | downregulated |
| Homogentisate 1,2-dioxygenase | HGD | 0.79 | downregulated |
| Tubulin beta-4A chain | TUBB4A | 0.79 | downregulated |
| Bromodomain-containing protein 9 | BRD9 | 0.79 | downregulated |
| Coagulation factor XIII A chain | F13A1 | 0.79 | downregulated |
| Probable ATP-dependent RNA helicase DDX60 | DDX60 | 0.78 | downregulated |
| Schlafen family member 5 | SLFN5 | 0.78 | downregulated |
| Mucin-13 | MUC13 | 0.78 | downregulated |
| Ankyrin repeat domain-containing protein 20A4 | ANKRD20A4 | 0.78 | downregulated |
| Soluble calcium-activated nucleotidase 1 | CANT1 | 0.77 | downregulated |
| Fibronectin | FN1 | 0.77 | downregulated |
| Ribokinase | RBKS | 0.77 | downregulated |
| E3 ubiquitin-protein ligase TRIM32 | TRIM32 | 0.77 | downregulated |
| Kelch-like protein 29 | KLHL29 | 0.77 | downregulated |
| Homeobox protein cut-like 2 | CUX2 | 0.77 | downregulated |
| Complement decay-accelerating factor | CD55 | 0.77 | downregulated |
| Myosin-4 | MYH4 | 0.76 | downregulated |
| Vitronectin | VTN | 0.76 | downregulated |
| Collagen alpha-1(XII) chain | COL12A1 | 0.75 | downregulated |
| 2′-5′-oligoadenylate synthase 2 | OAS2 | 0.74 | downregulated |
| Probable global transcription activator SNF2L2 | SMARCA2 | 0.74 | downregulated |
| Zinc finger protein 181 | ZNF181 | 0.74 | downregulated |
| Cyclic nucleotide-binding domain-containing protein 2 | CNBD2 | 0.74 | downregulated |
| T-complex protein 11-like protein 1 | TCP11L1 | 0.74 | downregulated |
| Ubiquitin-like protein ISG15 | ISG15 | 0.74 | downregulated |
| Hemoglobin subunit delta | HBD | 0.74 | downregulated |
| Copine-2 | CPNE2 | 0.73 | downregulated |
| Hemoglobin subunit alpha | HBA1 | 0.73 | downregulated |
| Lysine-specific demethylase 2B | KDM2B | 0.73 | downregulated |
| Methyltransferase-like protein 7B | METTL7B | 0.73 | downregulated |
| ATP-binding cassette sub-family C member 9 | ABCC9 | 0.72 | downregulated |
| Keratin, type II cytoskeletal 73 | KRT73 | 0.72 | downregulated |
| Ellis-van Creveld syndrome protein | EVC | 0.71 | downregulated |
| Tripartite motif-containing protein 2 | TRIM2 | 0.70 | downregulated |
| E3 ubiquitin-protein ligase TRIM37 | TRIM37 | 0.70 | downregulated |
| DNA topoisomerase I, mitochondrial | TOP1MT | 0.70 | downregulated |
| Epidermal growth factor receptor kinase substrate 8-like protein 3 | EPS8L3 | 0.70 | downregulated |
| Ubiquitin thioesterase OTU1 | YOD1 | 0.70 | downregulated |
| F-box DNA helicase 1 | FBH1 | 0.70 | downregulated |
| Perilipin-2 | PLIN2 | 0.70 | downregulated |
| Stonin-2 | STON2 | 0.69 | downregulated |
| Ecotropic viral integration site 5 protein homolog | EVI5 | 0.69 | downregulated |
| GTPase-activating Rap/Ran-GAP domain-like protein 3 | GARNL3 | 0.68 | downregulated |
| Protein NDRG1 | NDRG1 | 0.68 | downregulated |
| E3 ubiquitin-protein ligase TTC3 | TTC3 | 0.68 | downregulated |
| Vomeronasal type-1 receptor 5 | VN1R5 | 0.67 | downregulated |
| Kyphoscoliosis peptidase | KY | 0.67 | downregulated |
| Leucine-rich repeat-containing protein 70 | LRRC70 | 0.66 | downregulated |
| Serpin B5 | SERPINB5 | 0.66 | downregulated |
| Dual specificity protein kinase CLK2 | CLK2 | 0.66 | downregulated |
| Probable ATP-dependent RNA helicase DDX58 | DDX58 | 0.65 | downregulated |
| Angiotensin-converting enzyme 2 | ACE2 | 0.65 | downregulated |
| Nitric oxide synthase, endothelial | NOS3 | 0.65 | downregulated |
| Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 | GFPT2 | 0.63 | downregulated |
| Serine/threonine-protein phosphatase 4 regulatory subunit 4 | PPP4R4 | 0.62 | downregulated |
| Succinate receptor 1 | SUCNR1 | 0.57 | downregulated |
| Methylcytosine dioxygenase TET3 | TET3 | 0.57 | downregulated |
| Complement component C9 | C9 | 0.54 | downregulated |
| Cellular tumor antigen p53 | p53 | 0.51 | downregulated |