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. 2024 Jan 19;15:1295693. doi: 10.3389/fimmu.2024.1295693

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Copyright © 2024 Dong, Guo, Yang and Ge

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Multiple boxplots illustrate the expression of PSME3 in cancer cell lines before and after cytokine treatment, as obtained from the TISMO web tool. Significance levels are indicated as follows: *, **, and *** represent P values of < 0.05, < 0.01, and < 0.001, respectively. (B) Multiple boxplots depict the expression of PSME3 in cancer cell lines before and after PDL1 or CTLA4 treatment, as obtained from the TISMO web tool. Significance levels are denoted as follows: *, **, and *** denote P values of < 0.05, < 0.01, and < 0.001, respectively. Based on drug sensitivity analysis in GDSC (Genomics of Drug Sensitivity in Cancer), the following are the top 15 drugs that are positively correlated (C) and negatively correlated (D) with PSME3 expression, as shown in the figure. *P<0.05, **P<0.01, NS (no significant differences).