Figure 4.

Histopathologic evaluation of lung injury from tree shrews after intratracheal instillation of LPS. (a) Gross finding of lungs from tree shrew represented obvious lobe discoloration. 3 lobes on the left side (L) and 4 lobes on the right side (R) of the whole lung of the tree shrew. (b) The whole lung pathological section of marked NO.7 lobe of the lung. (c) Representative images of pulmonary histopathology. The lung injury score (d), percentage of the pulmonary alveolar area (e), and mean alveolar number (f) of the LPS-induced tree shrew group. Black arrow: neutrophil, black arrowhead: macrophage, yellow arrowhead: erythrocyte, yellow arrow: hyaline membrane, yellow asterisk: exudate protein debris. ***p < 0.001 vs. PBS group (n = 6).